The recipient died 15 days later of multiple systemic complications. The patient was a 54-year-old man who received the heart of a 43-year-old man. Norm Shumway's first patient, the first adult human-to-human heart transplant in the United States, underwent surgery on January 6, 1968, at Stanford University School of Medicine in Palo Alto, California. The patient, a 58-year-old man who received the heart of a 24-year-old man, was still alive on October 23, 1968-the date of compilation of the world's earliest heart transplants worldwide. 2,3 Barnard performed his second transplant on January 2, 1968, also at Groote Schuur Hospital. The procedure, carried out under hypothermia rather than cardiopulmonary bypass, was technically successful however, the patient died 6½ hours after surgery with severe metabolic and respiratory acidosis. The recipient was an 18-day-old male infant who received the heart of a 2-day-old anencephalic male. The first human-to-human heart transplant in the United States and the second in the world was performed by Adrian Kantrowitz 3 days later, on December 6, 1967, at Maimonides Medical Center in Brooklyn, New York. The patient, a 54-year-old man, received the heart of a 25-year-old woman and survived 18 days until he died of pneumonia. Christiaan Barnard, also a friend of mine from the early days in Minneapolis, returned to South Africa, where he performed his epic operation on December 3, 1967, at the Groote Schuur Hospital in Cape Town. This transplant apparently “didn't count” because it was not human-to-human. The recipient was a 68-year-old man, but the donor was a chimpanzee the patient died 1 hour later of acute rejection. 2,3 The first heart transplant in the world to a human was performed by James Hardy at the University of Mississippi Medical Center in Jackson on January 23, 1964. Two 1968 publications in the American Journal of Cardiology provide similar information. ![]() ![]() My recollection is that Norm performed the first adult (human-to-human) heart transplant in the United States. He befriended me when I was the greenest of surgical trainees, fresh out of medical school at the University of Cincinnati Norm was about 32 years old. 1 Norm was my hero and mentor from the time I met him in 1955 at the University of Minnesota. Denton Cooley's fine editorial tribute to Norman Shumway.
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